Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort

• DOI: 10.20944/preprints202308.2161.v1
• Publication Date: 2023-09-01T08:32:37Z
• Authors: Ying Chen; Caiqin Hu; Zheng Wang; Junwei Su; Shuo Wang; Bin Li; Xiang Liu; Zhenzhen Yuan; Dan Li; Hong Wang; Biao Zhu; Yiming Shao
• Keywords: Humoral immunity; Cellular immunity; Booster dose; Antibody titer

Vaccination has proven highly effective against severe acute res-piratory syndrome coronavirus 2 (SARS-CoV-2), but the long-term immunogenicity and functional preserved im-mune responses of vaccines are needed to inform evolving evi-dence-based guidelines for boosting schedules. We enrolled 205 healthcare workers into a cohort study; all had received three doses BBIBP-CorV (China Sinopharm Bio-Beijing Company) inactivated vaccine. assessed SARS-CoV-2 specific binding antibodies, neutralizing antibody, peripheral T B cell responses. demonstrated that more robust antibody re-sponses were elicited by booster immunization compared primary vaccination. Neutralizing titers Omicron variant also efficiently elevated post homologous vaccine despite in lower titer prototype stain. In addition S humoral cellular immunity, induced N-specific ef-fector The third-dose vaccination led further expansion critical polyfunctional responses, likely an essential element protection. particular, func-tional role Tfh subsets immunity was suggested correlation between both CD4+Tfh CD8+Tfh with total anti-body, IgG, antibodies. Our study details generated seven-month follow up study. There is clear immunologic value homolo-gous boosters, consideration future strategies.