Increased Collagen I/ Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse

• DOI: 10.20944/preprints202312.0389.v1
• Publication Date: 2023-12-08T05:10:55Z
• Authors: Zahra Shabani; Joana Schurger; Xiaonan Zhu; Chaoliang Tang; Li Ma; Alka Yadav; Rich Liang; Kelly Press; Shantel Weinsheimer; Annika Schmidt; Calvin Wang; Abinav Sekhar; Helen Kim; hua su
• Keywords: Arteriovenous malformation

Background: Increase of collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow pressure changes. We hypothesized that COL I/COL is increased in the brain arteriovenous malformations (bAVMs), which associated with bAVM hemorrhage. Method: Surgically resected human samples mouse bAVMs induced three transgenic lines activin receptor-like kinase 1 or endoglin deletion endothelial cells focally. Colony-stimulating factor receptor inhibitor was used transiently deplete microglia. levels, hemorrhage, gene expression were analyzed. Results: The levels higher on than controls, Col mRNAs also bAVMs. degree microhemorrhage positively correlated I/Col ratios. Transient depletion microglia reduced Conclusion: are vessels, Depletion reduces hemorrhage mice