Unveiling the Enigma: Exploring the Influences of Sexual Hormones in Adpkd Women and the Urgency for Novel Insight

• DOI: 10.20944/preprints202312.1789.v1
• Publication Date: 2023-12-26T05:35:47Z
• Authors: Micaela Petrone; Martina Catania; Liliana Italia De...; Rebecca S. Degliu...; Kristiana Kola; Chiara Lupi; Matteo Brambilla ...; Stefano Salvatore; Massimo Candiani; Giuseppe Vezzoli; Maria Teresa Scia...

This in-depth review navigates the intricate relationship between gender, hormonal influences, and progression of autosomal dominant polycystic kidney disease (ADPKD), highlighting limited literature on this crucial topic. The study explores impact female sex hormones liver renal manifestations, uncovering gender-specific differences in progression. Actually therapy women with ADPKD remains a challenging issue is source concern regarding its potential outcomes, particularly at hepatic level. Notably, exhibit slower compared to men, attributed dynamics. sheds light role estrogen regulating pathways renin-angiotensin-aldosterone system, revealing complex interplay implications for cardiovascular health. Therapeutic considerations fertile ADPKD, including contraception options, are discussed, emphasizing necessity personalized approaches. In postmenopausal phase, evaluates replacement therapy, considering benefits risks context ADPKD. concludes by underscoring imperative need tailored treatment approaches patients, individual benefits. scarcity underlines call further research enhance our understanding optimal therapies ultimately paving way innovative therapeutic interventions.