Onion Polyphenols as Multi-Target-Directed Ligands in MASLD – a Preliminary Molecular Docking Study

• DOI: 10.20944/preprints202402.1735.v1
• Publication Date: 2024-03-06T02:50:00Z
• Authors: Maria Rosaria Par...; Anna Caterina Pro...; Maja Milanović; Giuseppe Guido Ma...; Nataša Milošević; Maja Ružić; Nataša Milić; Ludovico Abenavoli

A sedentary lifestyle associated with unregulated diets rich in high-calorie foods have contributed to the great prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) latterly, with up to 60% in high-risk population and 25% in the general population. The absence of specific pharmacological strategies for this syndrome represents one of the major problems in the management of MASLD patients. Lifestyle interventions and adherence to a healthy diet are the main cornerstones of current therapies. The identification of nutraceuticals useful in the treatment of MASLD appears to be one of the most promising strategies for the development of new effective and safe treatments for this disease. The onion, one of the most widely studied foods in the field of nutraceuticals, serves as an inexhaustible reservoir of potent compounds with various beneficial effects. The following preliminary study analyses, mediating in silico studies, the iteration of a library of typical onion compounds with 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Liver receptors X α and β as well as Peroxisome proliferator-activated receptors α and γ. In this study fort the first time promising smart molecules from the onion that could have a beneficial action in MASLD patients were identified.