An Immune Escape of Oral Squamous Cell Carcinoma Might Be Different in the Originating-Epithelium, Keratinized or Non-keratinized

• DOI: 10.20944/preprints202403.0398.v1
• Publication Date: 2024-03-11T04:53:52Z
• Authors: Yoshiaki Kistukawa; Chonji Fukumoto; Toshiki Hyodo; Yuske Komiyama; Ryo Shiraishi; Aya Koike; Shuma Yagisawa; Yosuke Kunitomi; Tomonori Hasegawa; Wataru Kotani; Kazuyuki Ishida; Takahiro Wakui; Hitoshi Kawamata

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases oral cancer. Cancer cells usually escape from immune system and acquire proliferative capacity invasive/metastatic potential. We have focused on the two checkpoints, PD-1/PD-L1 CD47/SIRPα in tumor microenvironment of squamous carcinoma (OSCC), performed a retrospective analysis expression seven immune-related factors (PD-L1, PD-1, CD4, CD8, CD47, CD56 CD11c), examined their correlation with clinicopathological status. As result, there were no significant findings relating several statuses. However, immune-checkpoint related (PD-1, PD-L1, CD47) highly expressed non-keratinized epithelium-originated tumors when compared to those keratinized tumors. It is interest that immunoediting via checkpoint-related was facilitated sites. Several researchers reported keratinization mucosal epithelia affected response, but our present finding first study show difference immunity originating-epithelium OSCC, or non-keratinized. Tumor immunity, an status OSCC might be different originating-epithelium,