Unselective Measurement of Tumor‐to‐Stroma Proportion in Colon Cancer at the Invasion Front– an Elusive Prognostic Factor. Original Patient Data and Review of the Literature

• DOI: 10.20944/preprints202404.0571.v1
• Publication Date: 2024-04-10T09:22:36Z
• Authors: Zsolt Fekete; Patricia Ignat; Amelia Cristina R...; Nicolae Todor; Alina-Simona Muntean; Liliana Resiga; Sebastian Curcean; Gabriel Lazar; Alexandra Gherman; Dan Eniu
• Keywords: Medicine (General); R5-920; colon cancer; fibrosis; tumor stroma; adjuvant treatment; stroma-to-tumor ratio; pathology markers; Article

Tumor to stroma ratio is a highly debated prognostic factor in the management of several solid tumors and there no universal agreement on its practicality. In our study we proposed confirm or dismiss hypothesis that simple measurement quantity an easy-to-use strong tool. We have included 74 consecutive patients with colorectal cancer who underwent primary curative abdominal surgery. The been grouped into stroma-poor (stroma <10%), medium-stroma (between 10 50%) stroma-rich (over 50%). proportion tumor ranged from 5% 70% median 25%. Very few, only 6.8% had tumors, 4% 89.2%tumors medium stroma. stroma, at any cut-off, statistically significant influence disease specific survival. This can be explained by low patient group inverse correlation grade. real-life complex nature stroma-tumor interaction has further elucidated.