Prognostic Evaluation of Piezo2 Channels in Mammary Gland Carcinoma

• DOI: 10.20944/preprints202405.0540.v1
• Publication Date: 2024-05-09T10:20:04Z
• Authors: Yolanda García-Mesa; Aline Rodrigues-F...; Francisco Javier ...; Raquel Martín-Sanz; María Asunción Gó...; Sandra Malmierca-...; Rocío Salazar-Blá...; Olivia García-Suárez; Jorge Feito
• Keywords: Mammary carcinoma

In the last decade a group of Ca2+ channels called Piezo were discovered, demonstrating decisive role in cellular response to mechanical stimuli and being essential biological behaviour cells regarding extracellular compartment. Several investigations have suggested potential carcinogenesis with tumor supressor some cases, but increased expression several high grade neoplasms. Regarding Piezo2 mammary gland neoplasms, early results protective Piezo2, posterior works resulted relationship between highly-aggressive triple negative phenotype breast carcinoma. A cohort 125 patients clinical follow up was chosen study clarify its implications, using same immunohistochemical valuation performed for other carcinoma parameters. Fisher exact identify relationships different variables. significant association found Ki67 proliferation index, not mitoses. The tendency most proliferative tumors diminished score Piezo2. similar perineurial invasion.