Derived Neutrophils to Lymphocyte Ratio Predicts Survival Benefit from TPF Induction Chemotherapy in Local Advanced Oral Squamous Cellular Carcinoma

• DOI: 10.20944/preprints202407.0387.v1
• Publication Date: 2024-07-09T06:39:07Z
• Authors: Fangxing Zhu; Xinyu Zhou; Yiyi Zhang; Zhihang Zhou; Yingying Huang; Zhong Laiping; Tongchao Zhao; Wenjun Yang
• Keywords: Induction chemotherapy

Background: To evaluate derived neutrophil to lymphocyte ratio (dNLR) in predicting the prognosis of patients with locally advanced oral squamous cell carcinoma (LAOSCC), and survival benefits from docetaxel, cisplatin, 5-FU (TPF) induction chemotherapy (IC); Methods: Patients a phase III trial involving TPF IC stage III/IVA OSCC (NCT01542931) were enrolled. Receiver operating characteristic curves built area under curve was computed determine dNLR cutoff points. Kaplan-Meier estimates Cox proportional hazards models used for longitudinal analysis; (3) Results: 224 identified (median age, 55.4 yr; range, 26 75 median follow-up, 90 months; 3.2 93 months); Cutoff points 1.555. Multivariate analysis showed an independent negative predictive factor (overall (OS): hazard (HR) = 1.154, 95% confidence interval (CI): 1.018-1.309, P 0.025, disease-free (DFS): HR 1.123, CI: 0.260-1.000, 0.050, local recurrence-free (LRFS): 1.134, 1.002-1.283, 0.047, distant metastasis-free (DMFS): 1.146, 1.010-1.300, 0.035). Low combining cTNM disease predicts benefit [OS (χ² 4.674, 0.031), DFS 7.134, 0.008), LRFS 5.937, 0.015) DMFS 4.832, 0.028)]; (4) Conclusions: is LAOSCC patients. low can IC.