The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought

• DOI: 10.20944/preprints202408.0831.v1
• Publication Date: 2024-08-15T00:19:37Z
• Authors: Tatyana Veremeyko; Natalie Barteneva; Ivan Vorobyev; Eugene D. Ponomarev
• Keywords: Remyelination

Neurologic disorders such as traumatic brain injury, multiple sclerosis, Alzheimer’s disease, and drug-resistant epilepsy have a high socioeconomic impact around the world. Current therapies for these are often not effective. This creates demand development of new therapeutic approaches to treat disorders. Recent data suggest that autoreactive naturally occurring immunoglobulins produced by subsets B cells called B1 combined with complement actively involved in processes restoration neuronal functions during pathological conditions remyelination. The focus this review is discuss possibility creating specific antibodies can activate fix enhance survival promote central nervous system repair after injuries associated many types neurodegenerative diseases.