The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature

• DOI: 10.20944/preprints202408.0846.v1
• Publication Date: 2024-08-15T00:19:37Z
• Authors: Peyton Harris; Aaron Farberg; Janine Hopkins; Liqiao Ma; Donna Serure; Blake Robbins; Candace Osborne; Luis Bravo; Pauline Lausser; Amanda Boatner

Introduction Image Guided Superficial Radiation Therapy (IGSRT) is a novel technology which combines traditional superficial radiation therapy (SRT) with high resolution dermal ultrasound (HRDUS) to treat non-melanoma skin cancers (NMSC). Since development, IGSRT use has expanded dramatically in outpatient clinics. We review the literature and state of art operating principles US dermatologic practices. Materials Methods A search electronic databases (Medline, Pubmed, Cochrane Library, Science Direct) combined various authors’ published unpublished documents, procedures clinical experience were synthesized for this paper. Results Studies have demonstrated consistently delivers cure rates( >99%) low complications early stage (stage 0, I, or II) squamous cell basal carcinomas. Control rates are statistically superior non-image guided SRT external beam (XRT) as well Mohs Micrographic Surgery(MMS). This improvement attributed in-vivo tumor visualization via HRDUS using an interdisciplinary approach deliver care. clinic NMSCs become common practice continues expand. Conclusion While safety cosmetic benefits SRT/XRT been long documented, represents significant leap forward efficacy (statistically significant) by adding imaging. rival appear on one study surpass control obtained MMS. contributing factor success may be availability team that includes dermatologists, therapists, oncologists medical physicists. The rates, minimal side effects, favorable cosmesis ability multiple lesions per session establishing modality standard first line dermatology represent most effective option non-surgical treatment NMSC date.