Tuberculous Pleural Effusion-Derived Exosomal miR-130-3p and miR-423-5p Promote the Proliferation of Lung Cancer Cells via Cyclin D1

• DOI: 10.20944/preprints202408.1198.v1
• Publication Date: 2024-08-19T00:43:15Z
• Authors: Hyun-Jung Kang; Sangho Yun; Seung-Ho Shin; Dong Hyuk Youn; Ga-Hyun Son; Jae Jun Lee; Ji Young Hong
• Keywords: Exosome

Epidemiologic studies have shown an association between tuberculosis and lung cancer. The al-tered tumor microenvironment after infection appears to contribute cancer pro-gression. Pleural effusions are enriched in exosomes, which act as mediators of intercellular communication. We hypothesized that tuberculous pleural effusion (TPE)-derived exosomes mediate Then we examined the interaction TPE-derived cells. Exosomal miRNA profiling TPE was performed using a microRNA array. An vitro cell experiment vivo mouse xenograft model were used evaluate effects select exosomal microRNAs. exosome treatment en-hanced growth A549 cells both nude model. Neighboring observed take up promoted inva-sion. Exosome-mediated transfer microRNAs, including miR-130b-3p miR-423-5p, activated cyclin D1 signaling increased expression phos-phorylated p65, transcription factor. Inhibitors miR-130b miR-423-5p sup-pressed promotion by derived reduced p65 D1. These results suggest TBE-derived miRNAs can serve novel therapeutic target fibrosis-induced