Circular RNA Vaccines: Pioneering the Next-Gen Cancer Immunotherapy

• DOI: 10.20944/preprints202409.2216.v1
• Publication Date: 2024-09-30T02:53:29Z
• Authors: Uddalak Das; Soupayan Banerjee; Meghna Sarkar; Fathah Muhammad; Tanveen Kaur Soni; Madhumita Saha; Gayatri Pradhan; Bhaskarjyaa Chatt...
• Keywords: Cancer Immunotherapy

Circular RNA (circRNA) vaccines are emerging as a revolutionary strategy in cancer immunotherapy, offering novel mechanisms for inducing robust and durable immune responses. Unlike traditional linear mRNA vaccines, circRNAs exhibit exceptional stability, enhanced translational efficiency, resistance to exonuclease degradation, making them ideal candidates vaccine development. This review delves into the fundamental principles underlying circRNA biology, highlighting their unique structural advantages potential. We examine recent advancements design, focusing on application oncology. As circRNA-based is relatively approach, accounts of all major studies describing efficacy have been discussed. To maximize anti-cancer effects we also investigate combination with other immunotherapeutic modalities such checkpoint inhibitors adoptive cell therapies. Large-scale manufacturing, immunogenicity optimization, delivery systems, challenges future directions sector study aims thoroughly analyse state-of-the-art potential applications exciting possibilities next-generation