Involvement of Campylobacter Species in Spotty Liver Disease Like Lesions in Broiler Chickens Detected at Meat Inspections in Miyazaki Prefecture, Japan

• DOI: 10.20944/preprints202411.0651.v1
• Publication Date: 2024-11-13T05:21:46Z
• Authors: Piyarat Jiarpinitnun; Akira Iwakiri; Naoyuki Fuke; Pornsawan Pongsawat; Takako Taniguchi; Chizuru Miyanishi; Satomi Sasaki; Yuto Matsui; Taradon Luangtongkum; Kentaro Yamada; Naoaki Misawa
• Keywords: avian vibrio hepatitis (AVH); spotty liver disease (SLD); QH301-705.5; poultry; <i>Campylobacter</i> spp.; Biology (General); liver; broiler; Article

Spotty liver disease (SLD) affects free-range laying hens, leading to mortality and reduced egg production. Campylobacter species, including a novel strain, hepaticus, have been associated with SLD cases worldwide. However, the cause of like lesions found in broilers Japan is still remains unclear. The present study aimed investigate involvement Cam-pylobacter spp. broiler by conducting microbiological, molecular, serological, histopatho-logical, immunohistopathological examinations using specimens liver, bile, cecum, serum from SLD-like non-SLD chickens. C. jejuni was predominantly isolated detected approximately 40% both livers livers, no significant difference between them. While hepaticus neither nor this study. Gross his-topathology revealed multifocal necrotizing hepatitis, suppurative granulomatous cholangiohepatitis. Hepatitis stages classified as subclinical, acute, chronic hepatitis. more frequently acute-stage high IgG an-tibody levels were noted subclinical SLD-like-affected chickens, indicating infection. Immunohistochemical also supported these findings. findings suggest that he-paticus not involved Japan, but translocation in-testines may be contributing factor.