Development and Characterization of Hyaluronic Acid Graft-Modified Polydopamine Nanoparticles for Antibacterial Studies

• DOI: 10.20944/preprints202411.1142.v1
• Publication Date: 2024-11-19T01:21:57Z
• Authors: Shu Li; Jia Li; Jun Xing; Ling Li; Long Wang; Cai Wang
• Keywords: Characterization; Antibacterial peptide

The problem of antibiotic abuse and drug resistance is becoming more serious. in recent years, polydopamine (PDA) nanoparticles have been recognized as a potential antimicrobial material for photothermal therapy (PTT) due to their excellent conversion efficiency unique ability.PDA capable rapidly converting light energy into heat under near-infrared (NIR) irradiation efficiently kill bacteria. In order solve the PDA's tendency aggregate precipitate, this study improved its stability by grafting hyaluronic acid (HA) on surface PDA. Using dopamine raw materials, was grafted onto self-polymerization Michael addition reactions alkaline conditions obtain PDA-HA modified nanoparticles. We confirmed successful scanning electron microscopy (SEM), Fourier infrared spectroscopy (FTIR), nuclear magnetic hydrogen spectrometry (¹H NMR), Raman (Raman) analysis other test methods. Near-infrared performance experiments showed that temperature solution increased irradiation, demonstrating performance. vitro had effects against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli), rate 100% irradiation. simple prepare provides new idea developing antibacterial which great clinical significance treatment bacterial infections.