Waning Trends in Prevalence and Intensity of Wuchereria bancrofti Transmission Over Ten Chemotherapy Rounds in Ghana

• DOI: 10.20944/preprints202501.2147.v1
• Publication Date: 2025-01-31T12:07:07Z
• Authors: Joseph Harold Nya...; Sellase Pi-Bansa; Joseph Quartey; Joseph Otchere; Worlasi Debi Kart...; Kwadwo Kyereme Fr...; Irene Owusu Donkor; Collins Ahorlu; Maxwell Alexander...; Bethel Kwansa-Bentum; Fred Aboagye-Antwi; Langbong Bimi; Michael David Wilson; Dziedzom Komi de ...; Samuel Kweku Dadzie; Daniel Adjei Boakye
• Keywords: Lymphatic Filariasis

Ghana’s lymphatic filariasis (LF) elimination was intensified by Global Programme to Eliminate Lymphatic in 2000. LF transmission interrupted some endemic district, yet, persistent others. This study investigated characteristics of Wuchereria bancrofti that potentially contribute districts after prolonged mass chemotherapy (≧15yrs) expected interrupt transmission. Participants’ finger-prick blood screened for antigenaemia and positives followed night detect microfilariae. The antigenaemia/microfilaraemia prevalence, implications W. transmission, microfilariae clearance using scoring method (SM) were assessed. Exactly 2973 individuals 33 found positive. Infected microfilaraemia 8 communities from the 4 districts. prevalence Antseambua, Asemkow, Badunu, Navio (Sanwu) Central, Atampiisi Bongo, Balungu Nabiisi 1.3/0.0, 0.8/0.3, 0.8/0.0, 1.2/0.0, 1.7/0.0, 3.1/0.9 respectively but none Ampeasem Obrayebona. Microfilariae density thick films/Sedgwick counts relatively higher Western Region (283.9/410.0) compared Upper East (44.5/25.0). clearance/reinfection observed (using SM). Currently, thresholds suggest competent vectors can sustain Ahanta West District (hotspot) cause possible reinfection/resurgence Bongo (control district).