Low Expression of SOD and PRX4 as Indicators of Poor Prognosis and Systemic Inflammation in Colorectal Cancer

• DOI: 10.20944/preprints202503.1654.v1
• Publication Date: 2025-03-24T01:03:16Z
• Authors: Sanghyun An; Hye Youn Kwon; Kwangmin Kim; Soo-Ki Kim; Cheol-Su Kim; Bora Kim; Hyejin Do; Youngwan Kim
• Keywords: Expression (computer science)

Oxidative stress, characterized by an imbalance between the levels of reactive oxygen species (ROS) and antioxidants, plays a critical role in cancer progression. However, prognostic significance antioxidant markers colorectal (CRC) remains unclear. This study aimed to evaluate expression tumor tissues investigate their association with clinicopathological features, survival, systemic inflammation. We retrospectively analyzed 70 patients CRC who underwent curative surgical resection. The tissue superoxide dismutase (SOD), glutathione peroxidase (GPX), peroxiredoxin 4 (PRX4), thioredoxin (TRX) were measured freshly fro-zen tissues, classified into high low groups using 1st quartile as cutoff. Associations ELISA characteristics, laboratory inflammatory markers, survival outcomes analyzed. Low SOD was significantly associated higher incidence distant metastases. Similarly, PRX4 correlated more aggressive including rates metastasis, poor differentiation, advanced T4 stage. Moreover, linked inflammation, reflected increased neutrophil counts neutro-phil-lymphocyte ratio. Although not statistically significant, exhibited worse 5-year disease-free survival. heightened inflammation CRC. Given aggressiveness such may serve potential therapeutic targets for treatment.