Pathogenicity of Bovine H5N1 Influenza Virus in Human, Dairy Cow, and Big Feline Animal

• DOI: 10.20944/preprints202503.1867.v1
• Publication Date: 2025-03-26T05:23:44Z
• Authors: Takuma Hayashi; Kenji Sano; Tetsuya Degawa; Ikuo Konishi
• Keywords: Animal health

Highly pathogenic avian influenza virus (HPAI/H5N1) has caused widespread infections in dairy cattle and poultry the United States. Sporadic cases of human HPAI/H5N1 have also been confirmed. To prevent establish treatments for infected individuals, researchers at medical institutions States are analyzing biological characteristics strains confirmed country from March to October 2024. In particular, health care staff such investigating infection with virus. Confirmed mainly involved adults who come into contact animals. causes mild illness, as conjunctivitis, is short-lived. Most patients improve or cured early antiviral treatment. However, on January 7, 2025, Louisiana State Health Department reported death a person believed through captive wild birds. Although unknown routes transmission reported, reports person-to-person limited. Therefore, our research team compared infectivity humans cows molecular pathological analysis mammary gland tissues obtained cows. The results revealed that more receptors viruses were expressed cow than tissues. Furthermore, silico can infect humans. other words, backbone molecule may mutate within host, resulting respiratory tissue lions expression both (α2.6SA) (α2.3SA) lion tissue, well angiotensin converting enzyme 2, receptor severe acute syndrome coronavirus 2. One guidelines should be emphasized HPAIV/H5N1 becoming pandemic. this manuscript, we express assessments current information prevention spread infection, including status vaccine development against