Human Microglia Models for NeuroHIV

• DOI: 10.20944/preprints202503.1922.v1
• Publication Date: 2025-03-28T00:52:39Z
• Authors: Priyanka Sarkar; Xu Wang; Wenhui Hu; Jian Zhu; Wen-Zhe Ho

Microglia are the primary target and reservoir of HIV infection in central nervous system (CNS) which contribute to HIV-associated neurocognitive disorder (HAND). However, studying microglia has been challenged by limited availability human microglial cells. To overcome this issue, investigators have developed various models for studies, including immortalized cell lines, latently infected clone, peripheral blood monocyte-derived (MMG), induced pluripotent stem (iPSC)-derived (iMg) containing cerebral organoids (MCOs) from iPSC. Though these used many laboratories, published data about their expression specific markers entry receptors is conflicting. In addition, there information feasibility applicability as a suitable model acute and/or latent infection. This review provides concise summary currently with focus on suitability NeuroHIV research.