First Insights on the Upcoming Role of Next-Generation PLLA-LASYNPRO™ in Aesthetic and Regenerative Medicine. A Survey of Experts—Foundations and Rationale<span style="mso-fareast-font-family: Tahoma;">

• DOI: 10.20944/preprints202504.0266.v1
• Publication Date: 2025-04-07T02:31:56Z
• Authors: Dario Bertossi; Maurizio Cavallini; Alessandra Camporese; Roberto Dell'Avan...; Nicola Kefalas; Enrico Massidda; Marco Papagni; Mariagrazia Patalano; Sandro Quartucci; Monica Renga; Adriano Santorelli; Chantal Sciuto; Gloria Trocchi
• Keywords: Font; First generation

How injectable collagen stimulators promote the neosynthesis of and other components extracellular matrix in connective tissues has typically been linked to an inflammatory foreign-body reaction (FBR). A shift from long-dominant FBR paradigm a new focus on non-inflammatory regeneration may have emerged with next-generation PLLA-LASYNPRO&amp;trade; microspheres CE-approved JUL&amp;Auml;INE&amp;trade; medical device, which preclinical studies suggest are negligibly likely trigger inflammation. survey subsequent discussions during board meeting held Milan, Italy, involved thirteen distinguished experts micro-invasive aesthetic medicine, plastic surgery, dermatology, led this document accompanying manuscript &amp;ldquo;First Insights Upcoming Role Next-Generation Aesthetic Regenerative Medicine. Survey Experts &amp;mdash; Practical Suggestions&amp;rdquo;. This first paper outlines initial insights discussion basis value rationale proposed for subdermal implants regenerative medicine.