Progress on Myelodysplastic Syndromes with a Perspective from Latin America

• DOI: 10.20944/preprints202504.1627.v1
• Publication Date: 2025-04-22T00:22:03Z
• Authors: Ana Lisa Basquiera; Verónica Andreoli; Sofía Grille; Carolina Bárbara ...

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by ineffective hematopoiesis, resulting in cytopenias, morphologic dysplasia hematopoietic lineages, and variable risk progression to acute myeloid leukemia. Significant advances the understanding MDS have been made recent years, largely due implementation molecular tools. Latin America is highly diverse region, both ethnically racially, often faces resource limitations that challenge broad applicability MDS. In this review, we discuss key genes implicated pathogenesis classification MDS, including those related germline predisposition syndromes, their relevance diagnosis, prognosis, therapeutic decision-making. We also highlight research efforts from present results survey assessing availability tools American centers.