Thyroid gland changes in patients with acromegaly.

• DOI: 10.20945/2359-3997000000247
• Publication Date: 2020-06-20
• Authors: Еmil Natchev; Silvia Vandeva; Roussanka Кovatcheva; Georgi Кirilov; Krassimir Kalinov; Sabina Zacharieva
• Keywords: Thyroid disease

Acromegaly is characterized by high neoplastic morbidity as a side effect of growth hormone (GH) hypersecretion. Increased incidence goiter, thyroid carcinoma, and dysfunction also reported. The aim the present study was to find prevalence goiter in patients with acromegaly determine its relationship disease activity, duration, presence secondary hypothyroidism.In cross-sectional period 2008-2012 were included 146 (56 men, 90 women) mean age 50.3 ± 12.4 years. activity function evaluated all patients. Thyroid ultrasonography performed calculate volume detect nodular goiter.Ninety-one determined have an active disease, 55, controlled disease. without previous surgery 37.6 38.8 mL. According significantly higher (38.5 45.4 mL vs. 27.2 18.4 mL, p = 0.036). A weak positive correlation found between insulin-like factor 1 (IGF-1) whole group females (R 0.218; 0.013, R 0.238; 0.037, respectively). There no significant duration GH level both sexes. hypothyroidism had twofold smaller volume, relative rest group. 39%, female male percentage ratio 1.73. Goiter diagnosed 87% patients, including diffuse (17.1%) (69.9%), difference or hypothyroidism.Thyroid depends on complication. increased determines need regular ultrasound evaluation follow-up acromegaly. Arch Endocrinol Metab. 2020;64(3):269-75.