Prognostic significance of the pattern of pathological N1 lymph node metastases for non-small cell lung cancer

• DOI: 10.21037/jtd.2019.07.73
• Publication Date: 2019-08-31T06:11:18Z
• Authors: Sergej Griff; Samantha Taber; Torsten T. Bauer; Joachim Pfannschmidt
• Keywords: Univariate analysis; Mediastinal lymph node

In patients with non-small cell lung cancer (NSCLC) the pathologic lymph node status N1 is a heterogeneous entity, and different forms of involvement may represent prognoses. For methodological reasons, 8th edition TNM staging system for NSCLC makes no official changes to N descriptor. However, there evidence that subforms disease are associated prognoses, it now recommended clinicians record number affected nodes nodal stations further analyses. this investigation we sought determine whether levels types had significantly 5-year survival rates.We retrospectively identified 90 (61 men, 29 women), who were treated between 2008 2012 found have tumor sizes corresponding T1 or T2. All in curative intent surgical resection systematic mediastinal hilar dissection.The overall rate was 56.3%. univariate analysis, lower stage histology other than large-cell carcinoma better long-term survival. Patients solitary metastases also longer disease-free those multiple metastases. multivariate Union International Cancer Control (UICC) IIB independently worse survival, while pneumonectomy, compared lobar sublobar resection, survival.Although did not observe significant prognostic differences subcategories within our patient population, analyses yield results. Therefore, these data highlight need large, well-designed multicenter studies confirm clinical significance subcategories.