Bronchoscopic deployment and implantation of Diffusing alpha-emitters Radiation Therapy into the lung and mediastinum for treatment of lung cancer: a pre-clinical safety and feasibility study

• DOI: 10.21037/tlcr-23-639
• Publication Date: 2024-01-30T00:59:47Z
• Authors: Ali Sadoughi; Abhishek Sarkar; Carol Novotney; Christine Chan; Gerardo Moreno; Stephanie Oren; Lior Moss; Kobi Aharoni; Saleem Eben Bari; Nir Edery; Nitin Ohri
• Keywords: Histopathology

Radiotherapy is a standard treatment modality in cancer therapy, particularly for lung cancer. Diffusing alpha-emitters Radiation Therapy sources (hereafter, "Alpha DaRTs") are fixed with Ra-244 (half-life =3.6 days) that releases alpha-emitting atoms into the tumor tissue to an effective range of few millimeters.