Brachial Plexopathy Following Use of Recombinant Human BMP-2 for Treatment of Atrophic Delayed Union of the Clavicle

• DOI: 10.2106/jbjs.cc.n.00187
• Publication Date: 2015-09-24T03:04:21Z
• Authors: John R. Matthews; David S. Margolis; Eileen Wu; Lisa M. Truchan
• Keywords: Brachial Plexopathy; Osteolysis

Case: Although recombinant human bone morphogenetic protein-2 (rhBMP-2) is approved for treatment of open tibial fractures and anterior lumbar interbody fusion, off-label use has been associated with complications such as local inflammation, osteolysis, dysphagia. This case report describes a patient treated rhBMP-2 an atrophic delayed union clavicular fracture who subsequently developed profound motor sensory brachial plexopathy. Conclusion: Use near peripheral nerves may cause neuropathy. should be considered prior to its in surgical sites proximity.