Unlocking the Healing Potential

• DOI: 10.2106/jbjs.rvw.23.00141
• Publication Date: 2023-11-16T19:17:03Z
• Authors: Hania Shahzad; Maximillian Lee; Vikas Munjal; Cole Veliky; Elizabeth Yu
• Keywords: Cannabinoids; Humans; Pain Management; Pain; Dronabinol; 3. Good health; Cannabis

» Cannabinoids, such as D9-tetrahydrocannabinol and cannabidiol, interact with endocannabinoid receptors in the central nervous system immune system, potentially offering pain relief. The entourage effect, resulting from interaction of multiple cannabis components, may enhance therapeutic impact efficacy, making them promising candidates for exploring relief spine operations, known to be among most painful operative procedures.» use cannabinoids management requires careful consideration safety, including their cognitive psychomotor effects, potential cardiovascular risks, risk dependence, mental health implications, drug interactions.» Few studies have analyzed cannabinoid relation surgery, variable results reported, indicating possible effects on reoperation rates, mortality, complications, postoperative opioid use, length hospital stay.» Current knowledge gaps exist understanding exploration different administration routes, timing, dosage, specific outcomes. In addition, mechanistic explanations observed are lacking.» Ethical considerations related informed consent, medical expertise, societal impact, legal compliance must also thoroughly addressed when considering utilization spinal pathologies back treatment.