Association between NMD3 and symptoms of Parkinson’s disease in Chinese

• DOI: 10.21203/rs.2.10047/v1
• Publication Date: 2019-06-03T19:27:35Z
• Authors: Hui Wu; Hui Li; Zhiqiang Shi; Jiajia Tang; Shuya Mei; Tianyi Ai; Zhenzhou He

Abstract Bcakground

Parkinson's disease (PD) is a progressive degenerative disorder of the basal ganglia that not only affects the initiation and execution of voluntary movements, but also nonmotor features. The aim was to investigate the association between NMD3 and symptoms of PD patients in Chinese.

Methods

217 PD patients were recruited in this study. All patients were evaluated by Sniffin’ Sticks 16 (SS-16), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39) and MDS - Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

Results

NMD3 carriers had worse cognitive function (MMSE: p 0.042, NMD3 wildtype: 27.44 ± 2.89, NMD3 carriers: 26.31 ± 3.79; MoCA: p 0.005, NMD3 wildtype: 23.15 ± 4.20, NMD3 carriers: 20.75 ± 6.68).

Conclusions

The recessive and overdominant model of GALC rs8001572 was associated with the presence of sensitive to light.