Innate lymphoid cells at the maternal-fetal interface: Implications in preterm labor

• DOI: 10.21203/rs.2.11586/v1
• Publication Date: 2019-07-18T13:44:12Z
• Authors: João Fernando Per...; Paulo Rodrigues S...; Ana Areia; Jani Sofia Almeida; Vera Alves; Manuel Santos-Rosa; Anabela Mota-Pinto
• Keywords: Proinflammatory cytokine; Innate lymphoid cell; Cord blood

Abstract Background: Preterm labor (PTL) is one of the major causes neonatal morbidity and mortality worldwide. It commonly accepted that act giving birth final step in a proinflammatory signaling cascade, orchestrated by an intrauterine milieu coupled to hormonal cues. Consequently, inflammatory process plays pivotal role during pathogenesis human labor, both term preterm deliveries. The aim this work was analyze abilities innate lymphoid cells (ILCs), specifically ILC3 NCR- cells, as mediators elucidate their pregnancy. Accordingly, we hypothesize altered ILC numbers may prompt (PTL). Methods: We analyzed thirteen full (FTL) seven PTL pregnant women for presence ILCs. ILCs were isolated characterized from maternal peripheral blood, maternal-fetal interface, cord blood samples, using flow cytometry. For group analysis, two-way ANOVA performed. Each data set student t-test with confidence interval 95%. Results: A tendency decreased samples compared those FTL observed. Additionally, significantly increased groups, when ILC3NCR+. Conclusion: Our results support potential instigation labor. Moreover our highlights importance actions regulation