A comparison of co-expression networks in silk gland reveals the causes of silk yield increase during silkworm domestication

• DOI: 10.21203/rs.2.12747/v1
• Publication Date: 2019-08-13T19:54:57Z
• Authors: Qiu-Zhong Zhou; Ping Fu; Shu-Shang Li; Chang-Jiang Zhang; Quan-You Yu; Chuan-Zhen Qiu; Hong-Bo Zhang; Ze Zhang
• Keywords: Fibroin; Sericulture; Sericin; Bombyx

Abstract Background Long-term domestication and breeding selection have led to that silk yield of the domestic silkworm (Bombyx mori) increased several times higher than its wild ancestor (B. mandarina). However, little is known about molecular mechanisms increase during domestication. Results Based on dynamic patterns functional divergence in gland between silkworms, we found at early intermediate stages development, up-regulated genes mainly include DNA integration, nucleic acid binding transporter activity, which related division growth cell. This has posterior (PSG) significantly more cells (“factories” fibroin protein synthesis) silkworm. At late stage are enriched processing ribosome pathways, suggesting synthesis efficiency greatly improved The synthetic capacity proteins increased, however, sericin decreased relative reflects silkworms been under different pressures. Importantly, network co-expressed with silk-coding for much larger Furthermore, subject artificial those Conclusion Our results revealed involved improvement a biological system includes not only expansion “factories” (cells PSG) but also high expression as well production such energy, transport, pathway genes. In addition, combination comparative multi-omics method used this study provides methodology reference investigation formation complex trait other animals.