Pediatric Brain tumors in Southeast Nigeria; An 8-year prospective longitudinal cohort study

• DOI: 10.21203/rs.2.13963/v1
• Publication Date: 2019-09-04T18:51:07Z
• Authors: Enoch Uche; Nkechi Judith Uche; Obinna V Ajuzieogu; Dubem Amuta; ephraim Onyia; Chris Eke; John Okafor; John-Kennedy Emejulu; Wilfred Mezue; Matt Ryttlefors; Magnus Tisell
• Keywords: Craniopharyngioma; Chi-square test

Abstract Background: Pediatric brain tumors (PBT’s) from previous studies are associated with poor outcomes in our subregion. Methods. An 8 -year single center prospective study. All cases investigated neuroimaging and treated were enrolled. Data was analyzed SPSS (Inc) Chicago IL, USA version 23. Chi Square test, One-way Anova confidence limits used to evaluate associations using the 95% level of significance. Patients followed up for a range 1 7.5 years mean 4.9 ±1.3years. Ethical approval obtained Results: 95 patients enrolled, 84 satisfied study criteria. There 45 males 39 females, M: F=1.1. The age 9.9±2.7 95%CI 9 months 16 years. most common symptom headache supratentorial lesions (73%) gait disturbance (80.2%) infratentorial lesions. More location (45(54.2%), while 33(37.1%) infratentorial. Craniopharyngiomas (n=19), medulloblastomas(n=17) astrocytomas (n=11) tumors. Hemoglobin genotype(AA AS) had some influence on tumor phenotype, Odds ratio 8.9 3.3 medulloblastoma craniopharyngioma. 69 microsurgically resected 14 radiotherapy alone. 30-day mortality operated is 7.9±1.3%. Overall 1-year 5-year survival 67.9% 53.6 % respectively. Survival rates varied among treatment groups (X2=8.9, P=0.017). Conclusion: profile this series suggests improvement comparison region.