Peptides regulating gastrointestinal function in children before and after hematopoietic stem cell transplantation

• DOI: 10.21203/rs.2.16711/v1
• Publication Date: 2019-11-01T19:33:53Z
• Authors: Magdalena Rej; Szymon Skoczeń; Danuta Pietrys; Kinga Kwiecińska; Przemysław J. Tom...; Małgorzata Wójcik; Wojciech Strojny; Agnieszka Dłużnie...; Katarzyna Klimasz; Kamil Fijorek; Michał Korostyński; Marcin Piechota; Walentyna Balwierz
• Keywords: Glucagon-like peptide-2

Abstract Gastrointestinal tract function and it's integrity are controlled by a number of peptides whose secretion is influenced severe inflammation. In stomach the main regulatory peptide ghrelin. For upper small intestine cholecystokinin glucagon-like peptide- 1 secreted, while fibroblast growth factor-21 secreted several organs, including liver, pancreas, adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this peptides. The aim study was to determine fasting plasma concentrations ghrelin, cholecystokinin, glucagone- like peptide-1, factor -21, their gene expressions, before 6 months after hematopoietic transplantation. 27 children were studied. C ontrol group included 26 healthy children. Acute graft versus host disease diagnosed in 11 patients (41%, n=27). Median pre-transplantation , glucagone as well significantly lower compared with control group. contrast, median near-significantly higher than A comparison pre- post-transplantation groups revealed studied (except factor-21) respective expressions post–hematopoietic transplant M edian peptide-1 decreased features acute disease. Moreover, negative correlation between severity found. Increased gastrointestinal regulation be caused stimulation regeneration injured organ. Measurement these parameters may useful method assessment complications