Prognostic factors for hospital mortality in patients with idiopathic pulmonary fibrosis

• DOI: 10.21203/rs.2.18451/v1
• Publication Date: 2019-12-09T22:32:49Z
• Authors: sheau-ning yang; Diahn-Warng Perng; Mei-Ing Chung; Hsin-Kuo Ko; Po-Chun Lo; Yuh-Lih Chang; Chia-Chen Hsu; Hsin-Yi Huang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Abstract Background: The prognostic factors for hospital mortality in patients with idiopathic pulmonary fibrosis (IPF) have not been characterised well. We aimed to determine the impact of respiratory hospitalisation on patient outcomes and predictors mortality. Methods: Data from IPF was collected analysed two cohorts, TaiwanNational Health Insurance Research Database (NHIRD) between 2001 2011 a national medical centre (NMC)between 2001and 2015. Results: 122 NHIRD cohort were recruited. median survival lower (25/122, 29.8%) compared non-respiratory hospitalisation(59/122, 48.4%) (2.3 years vs 9 years, p =0.007). In NMC (N=47), acute deterioration (ARD) (30/47,63.8%) non-ARD (17/47, 36.2%) had poor (0.9 monthsvs 29.6 months, <0.001). differences cohorts associated age, causes hospitalisation, mechanical ventilation comorbidities. hospitalised ARD statistically higher GAP score, oxygenation, C-reactive protein levels, neutrophil counts serum albumin level those hospitalisation. For both in-hospital 1 year mortality, multivariate analysis adjusting characteristics confirmed independent predictive steroid pulse therapy, exacerbation ventilation. Conclusions: negatively impacted outcomes, may be utilised refine management IPF.