In vitro antimalarial activity of selected medicinal plants native to Tigray region of Ethiopia

• DOI: 10.21203/rs.2.19327/v1
• Publication Date: 2019-12-19T20:32:31Z
• Authors: Gebretsadkan Hint...; Sarah D’Alessandro; Silvia Parapini; Nicoletta Basilico; Aman Karim
• Keywords: Aloe Vera

Abstract BackgroundVarious medicinal plants are used as alternative remedies for the management of malaria, an important infectious disease responsible around 228 million cases and 405,000 deaths worldwide in 2018. The worsening is highly associated to emergence drug-resistant parasites. Hence, search new antimalarial agents from traditionally most viable approach. current study was aimed evaluate vitro antiplasmodial property Aloe elegans , monticola Capparis tomentosa, Hygrophila schulli Tephrosia gracilipes extracts.Methods Leaf latexes were collected whereas cold maceration with 70% ethanol prepare extracts roots tomentosa leaves . activity against asexual gametocyte stages tested using parasite lactate dehydrogenase assay luciferase assay, respectively. Cell cytotoxicity assessed on human microvascular endothelial cells by MTT assayResults Of five selected plants, leaf latex showed best both stage V gametocytes Plasmodium falciparum ethanolic extract also stages. On contrary, Tephrosa gracilipe s inactive.Conclusion Findings this may partly support acclaimed traditional use mild moderate malaria.