Gut microbiota regulates autism-like behavior by mediating vitamin B6 metabolism in EphB6-deficient mice

• DOI: 10.21203/rs.2.21492/v2
• Publication Date: 2020-02-06T19:39:20Z
• Authors: Jian-Ming Li; Ying Li; Zheng-Yi Luo; Yu-Ying Hu; Yue-Wei Bi; Jian-Ming Yang; Wen-Jun Zou; Yun-Long Song; Shi Li; Tong Shen; Shu-Ji Li; Lang Huang; Ai-Jun Zhou; Tian-Ming Gao
• Keywords: Gut–brain axis

Abstract Background Autism spectrum disorder (ASD) is a developmental with limited effective pharmacological treatments for the core autistic symptoms so far. Increasing evidences, especially clinical studies in ASD patients, suggest functional link between gut microbiota and development of ASD. However, mechanisms linking brain dysfunctions (gut-brain axis) are still not well-established. With genetic mutations down-regulated expression patients ASD, EPHB6 , which also important homeostasis gut, has been generally considered to be candidate gene Nonetheless, role mechanism involved regulating have unclear. Results Here, we found deletion EphB6 induced autism-like behavior disturbed mice. More importantly, transplanting fecal from EphB6-deficient mice resulted antibiotics-treated C57BL/6J Meanwhile, wild-type ameliorated At metabolic levels, led vitamin B6 dopamine defects cellular excitation/inhibition (E/I) imbalance medial prefrontal cortex was by microbiota-mediated metabolism Conclusions Our study uncovers key regulation social mediating metabolism, synthesis E/I balance mice, suggesting new strategies understanding treatment