Association of 5p15.2 and 15q14 with High Myopia in Tujia and Miao Chinese Populations

• DOI: 10.21203/rs.2.21557/v1
• Publication Date: 2020-01-22T20:44:00Z
• Authors: Junwen Wang; Fang Liu; Xiusheng Song; Tuo Li
• Keywords: Sanger sequencing

Abstract Background In previous studies, rs6885224 and rs634990 polymorphisms have been reported to be associated with high myopia in many populations. Tujia Miao minority area, there is still no report on whether the two SNPs are myopia, so we conducted a replication study evaluate association of single-nucleotide 5p15.2 15q14 regions Chinese Methods We performed comprehensive meta-analysis 3816 cases 4516 controls assess region were myopia. Then total 804 individuals enrolled our study. Genomic DNA was extracted from venous leukocytes. The interest, rs634990, genotyped by Sanger sequencing. frequencies alleles genotypes analysed using χ 2 tests, ORs 95%CIs calculated. Results According results meta-analysis, CTNND2 gene showed [ p =0.893, OR=1.005, 95%CI (0.936-1.079)]. However, significant <0.05, OR=0.818, (0.750-0.892)]. study, neither nor any allele frequency analysis rs6885224, =0.175, OR=0.845, 95%CI=0.662-1.078, =0.087, OR=0.84, 95%CI=0.687-1.026. genotype =0.376, =0.243. Conclusions Our show that significantly while not. Nevertheless, these This first involving ethnic groups Enshi areas, but sample size needs expanded more stringent inclusion exclusion criteria need formulated verify this result.