The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trial

• DOI: 10.21203/rs.2.388/v2
• Publication Date: 2019-04-25T18:32:49Z
• Authors: Zhaojun Qin; Chunyan Xiang; Hongbo Li; Tingting Liu; Leyun Zhan; Zhengyuan Xia; Min Zhang; Jianpin Lai
• Keywords: Dexmedetomidine; Ropivacaine

Abstract Background: Intravenous dexmedetomidine is known to attenuate stress response in patients undergoing laparoscopic surgery. We investigated whether the addition of highly selective alpha-2 adrenergic agonist into ropivacaine for ultrasound-guided transversus abdominis plane block could inhibit during surgery, and determined optimal dose it. Methods: One hundred twenty-five gynecological surgery were included this prospective randomized double-blind study. Patients received general anesthesia with or without a total 60 ml 0.2% combination low (0.25 µg/kg), medium (0.50 µg/kg) high (1.0 four-quadrant block( n = 25). The primary outcomes marker levels operation. Results: twenty completed study protocol. Dexmedetomidine added significantly reduced serum cortisol, norepinephrine, epinephrine, interleukin-6, blood glucose, mean arterial pressure heart rate dose-dependent manner (P < 0.05), accompanied decreased anesthetic opioid consumption operation but induced higher incidences bradycardia than 0.05). Conclusion: at 0.5 µg/kg limited impact on laparoscopy