Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens

• DOI: 10.21203/rs.2.9864/v3
• Publication Date: 2019-10-11T21:18:36Z
• Authors: Bo Li; Yunchun Zou; Liwen Li; Hongwei Deng; Wei Mi; Xing Wang; Ximin Yin
• Keywords: Monocular deprivation

Abstract Background : Exploring the role of vasoactive intestinal peptide (VIP) in lateral geniculate body (LGBd) visual development and studying therapeutic effect VIP on amblyopic kittens. Methods: Three-week-old domestic cats were divided into a control group (n = 10) monocular deprivation 20), with an eye mask covering right those deprived group. After pattern evoked potential (PVEP) recording confirmed formation amblyopia, left LGBd was isolated from 5 kittens each The remaining continued to be raised, intervention 5), Sefsol (caprylic acid monoglyceride, solution) 5) amblyopia non-intervention after removal mask. Three weeks later, PVEPs, immunohistochemistry mRNA expression compared across groups. Results: At 6 age, there significant differences P100 wave latency amplitude situ hybridization between (P < 0.05). 3 corresponding interventions, better than that Furthermore, treatment increased number immunohistochemical VIP-positive cells 0.05) average optical density positive > 0.05), as well mRNA-positive Conclusion s plays important development. Nasal administration can improve function neurons has certain amblyopia.