The Relationship Between Frailty and Schizophrenia: A Genetic Association and Mendelian Randomization Study

• DOI: 10.21203/rs.3.rs-3670648/v1
• Publication Date: 2023-11-28T19:32:46Z
• Authors: Ming-Gang Deng; Kai Wang; Fang Liu; Xiuxiu Zhou; Jiewei Liu
• Keywords: Mendelian Randomization; Causality; Genetic Association; Genome-wide Association Study; Genetic correlation

Abstract Importance Frailty was associated with elevated risks of various diseases and could induce many adverse outcomes in schizophrenia patients. However, the association causality between frailty are still unclear. Objective To investigate genetic schizophrenia. Design, Setting, Participants We obtained summary data related to from large-scale genome-wide studies European population. Genetic analyses were investigated 5 aspects: global correlation, local shared genomic loci, overlapped tissue enrichments, functional genes. The inferred via bidirectional Mendelian Randomization (MR) analyses. Main Outcomes Measures Results correlation presented they positively associated, demonstrated locally correlated three genomes. Furthermore, 111 loci found be jointly Additionally, enrichment summary-data-based MR variants have enrichments genes brain. Lastly, results implied there a causal relationship Conclusions Relevance Our study indicated that had plenty basis supported their causality. Further warranted validate these findings non-European populations.