Possible relationships between placenta and serum asprosin levels and pregnancy and spontaneous preterm births

• DOI: 10.21203/rs.3.rs-5988045/v1
• Publication Date: 2025-04-10T11:38:47Z
• Authors: Cihan GUL; Kazım UCKAN; Salih CIBUK

<title>Abstract</title> Objective Asprosin, a newly characterized adipokine, has been implicated in several physiological and pathological pathways. This study aimed to explore the association between serum placental asprosin concentrations occurrence of preterm birth, evaluating their potential as predictive biomarkers. Methods A total 75 participants were enrolled this cross-sectional categorized into four groups: early (delivery before 34 weeks, n = 15), late (34–37 term delivery (37–42 30), non-pregnant controls (n 15). Serum samples collected from all individuals, tissues obtained post-delivery pregnant participants. Asprosin quantified using ELISA, correlation analyses conducted determine associations with clinical variables. Results Significantly elevated levels detected both women births compared deliveries (p &lt; 0.008 for placental, p 0.001 serum). The highest noted group (placental: 18.88 ± 2.12 ng/ml; serum: 19.04 3.15 ng/ml). Strong inverse correlations identified gestational age r=-0.647, 0.01; r=-0.716, 0.01), neonatal birth weight (r=-0.683, 0.01). ROC analysis indicated cut-off values 16.58 ng/ml (placenta) 15.22 (serum) thresholds prediction. Conclusion Increased maternal are linked demonstrating duration infant weight. These results suggest role biomarker warranting further mechanistic investigations.