Deletion of an Enhancer in FGF5 is Associated With Ectopic Expression in Goat Hair Follicles and the Cashmere Growth Phenotype

• DOI: 10.21203/rs.3.rs-84328/v1
• Publication Date: 2020-10-02T16:27:40Z
• Authors: Yefang Li; Shen Song; Xuexue Liu; Yanli Zhang; Dandan Wang; Xiaohong He; Qianjun Zhao; Yabin Pu; Weijun Guan; Yuehui Ma; Lin Jiang
• Keywords: Cashmere goat; Introgression; Indel; SOX9; Capra hircus

Abstract BackgroundResearch on cashmere growth has a significant effect the production of and profound influence goat breeding. Whole-genome sequencing is powerful platform to rapidly gain novel insights into identification genetic mechanisms underlying fiber growth. ResultsIn this study, we generated whole-genome sequences 115 domestic goats from China, Nepal Pakistan, including 51 64 non-cashmere goats. We found genetically distinct clusters according their geographic locations but admixture or introgression may have occurred between Chinese Nepalese identified that fibroblast factor 5 gene ( FGF5 ) shows strong signature for positive selection in goat. The 505-bp indel variant at locus appeared be strongly associated with Functional validation showed insertion serve as an enhancer transcription binding, resulting increased upstream ConclusionsOur study provides useful information sustainable utilization improved conservation resources demonstrates mutation could potentially molecular marker