Diet Enriched in Saturated Fatty Acids Induces Liver Oxidative Stress and Elicits Inflammatory Pathways Prior to Metabolic Disruption in Perinatal Protein Undernutrition

• DOI: 10.2139/ssrn.4144055
• Publication Date: 2022-06-29T20:53:47Z
• Authors: Aiany C. S. Alves; João Henrique Cos...; Arthur Bassot; Carol Góis Leandro; Luciano Pirola; Mariana P. Fernandes; Beatrice Morio
• Keywords: Metabolic pathway

Aim: To evaluate the impact of a saturated fatty acid (SFA)-enriched diet (hyperlipidic, HL) in post-weaning offspring subjected to maternal protein restriction expression liver genes redox balance and inflammatory pathway.Main methods: Pregnant Wistar rats received either control (C) or low (LP, 8% protein) during gestation lactation. At weaning, pups C HL (+70% SFA) diets up 90 days life.Key findings: It was verified that circulating markers lipid metabolism function were not significantly altered among groups. The LP + group showed an increase oxidation (p<0.01). Likewise, there upregulation transcription NF-KB1 TNF-α (p<0.05) LP+HL when compared group. Post-weaning did alter pattern SOD1, SOD2, CAT, GPX1, GPX2, UCP2 groups, except for which higher fed than (+66%, p<0.05). For expression, CAT lower under both conditions (p<0.05). In contrast, SOD2 content twice high groups However, GPX1/2 similar between Regarding factors, enhanced PGC1α (+207%, p<0.05) PPARγ (+151%, levels vs. C.Significance: Data suggest induces oxidative stress, activation pathways, however without metabolic disturbance critical period development.