ABO Phenotype and Clinical Correlates of COVID-19 Severity in Hospitalized Patients

• DOI: 10.2144/fsoa-2021-0045
• Publication Date: 2021-06-12T12:54:25Z
• Authors: David J Hermel; Samantha R Spierl...; Carrie L Costantini; James R Mason; Zhubin J Gahvari; Alan Saven
• Keywords: Medicine (General); Hispanic; R; COVID-19; anemia; 3. Good health; 03 medical and health sciences; San Diego; R5-920; 0302 clinical medicine; male; Medicine; ABO blood type; Research Article

This study investigates the association between ABO blood phenotype and COVID-19 severity, measured by intensive care unit admission, need for intubation, hospitalization length and death. It further explores clinical predictors of COVID-19 severity within a primarily Hispanic demographic in San Diego County.We retrospectively reviewed 942 total patients, 473 with available blood type, hospitalized at five Scripps Health hospitals with COVID-19.No significant association was found between ABO phenotype and COVID-19 severity on multivariate analysis, while a diagnosis of anemia and male sex was associated with all severity outcomes on exploratory analysis.Our results provide relevant clinical correlates of COVID-19 severity and help better elucidate the association between ABO phenotype and COVID-19.