Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population

• DOI: 10.2147/cia.s156044
• Publication Date: 2018-03-04T22:26:37Z
• Authors: Nurgul Sikhayeva; Yerkebulan Talzhanov; Aisha Iskakova; Jarkyn Dzharmukhanov; Raushan Nugmanova; Elena Zholdybayeva; Erlan Ramanculov
• Keywords: Kazakh

Background: Ethnic differences exist in the frequencies of genetic variations that contribute to risk common disease. This study aimed analyse distribution several genes, previously associated with susceptibility type 2 diabetes and obesity-related phenotypes, a Kazakh population. Methods: A total 966 individuals belonging ethnicity were recruited from an outpatient clinic. We genotyped 41 single nucleotide polymorphisms (SNPs) other ethnic groups 31 these Hardy–Weinberg equilibrium. The obtained allele further compared publicly available data populations. Allele for (compared) populations pooled haplotype map (HapMap) database. Principal component analysis (PCA), cluster analysis, multidimensional scaling (MDS) used relationship between Results: Comparative studied SNPs showed significant differentiation among population was grouped Asian according Caucasian PCA. According MDS, results current show holds intermediate position Conclusion: high percentage observed world clustered populations, this result may indicate gene pool. Keywords: single-nucleotide polymorphism, population, diabetes, OpenArray