Intrinsic Capacity Deficits and 6-Month Outcomes in Older Adults with Acute LRTIs: A Multi-Center Study

• DOI: 10.2147/cia.s501592
• Publication Date: 2025-04-23T11:40:12Z
• Authors: Bingxuan Weng; Jin Jin; Lixue Huang; Wenshu Jiao; Mengyuan Wang; Xinyue Zhang; Xunliang Tong; Yanming Li
• Keywords: Center (category theory)

Intrinsic capacity (IC), representing an individual's physical and mental abilities, is associated with adverse outcomes. Acute lower respiratory tract infections (LRTIs) contribute to poor long-term prognosis, yet effective assessment intervention strategies remain limited. Given the critical role of IC in aging population, understanding its prevalence impact older adults LRTIs crucial for improving management strategies. This study aims characterize domains patterns deficits assess their influence on 6-month mortality re-hospitalization this population. was a multi-center prospective cohort conducted China. Patients aged over 65 years hospitalized acute were consecutively enrolled underwent evaluations upon admission between April 15, 2021, January 2023. Outcomes included re-hospitalization. Latent class analysis identified deficits, multivariable logistic regression models assessed associations deficit domains/patterns A total 1,001 patients included, mean age 76 (IQR: 69-84). Most (839, 83.8%) had at least one domain deficit. The rates 20.7% (190/933) 7.7% (70/914). More particularly cognition (OR 1.873) vitality 1.737) increased rates. Three distinct identified: relatively robust (73.5%), limited locomotion (18.6%), impaired cognition, vision, hearing group (7.9%). Compared group, significantly higher risk 2.025, 95% CI 1.388-2.932). prevalent LRTIs. Early detection targeted interventions may reduce improve patient