Completeness of<em> RET</em> testing in patients with medullary thyroid carcinoma in Denmark 1997&ndash;2013: a nationwide study

• DOI: 10.2147/clep.s183268
• Publication Date: 2019-01-09T19:54:56Z
• Authors: Jes Sloth Mathiesen; Jens Peter Kroustrup; Peter Vestergaard; Kirstine Stochholm; Per Løgstrup Poulsen; Åse Krogh Rasmussen; Ulla Feldt-Rasmussen; Sten Schytte; Stefano Christian...; Henrik Baymler Pe...; Christoffer Holst...; Jens Bentzen; Sören Möller; Mette Gaustadnes; Maria Rossing; Finn Cilius Nielsen; Kim Brixen; Anja Lisbeth Fred...; Christian Godballe
• Keywords: Danish

The completeness of REarranged during Transfection (RET) testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the on a population level is unknown. Similarly, it unknown if first Danish guidelines from 2002, recommending RET all MTC patients, improved Denmark. We conducted nationwide retrospective cohort study aiming to evaluate cohort. Additionally, we aimed assess before and after publication characterize who had not been tested.The included 200 identified 1997-2013. To identify tested December 31, 2014, cross-checked 1994-2014. tested, reviewed their medical records compared them tested.Completeness overall 87% (95% CI: 0.81-0.91; 173/200). In adjusted cohort, excluding diagnosed hereditary by screening, 83% 0.76-0.88; 131/158). Completeness 88% 0.75-0.95; 42/48) 81% 0.72-0.88) (89/110) guidelines, respectively. Patients higher median age at diagnosis those tested. Median time death shorter relative Denmark seems be than other cohorts. No improvement detected guidelines. addition, data indicate that advanced low life expectancy may serve prognostic indicators having likelihood missing compulsory test.