<p>Clinicopathological features and prognosis of AFP-producing colorectal cancer: a single-center analysis of 20 cases</p>

• DOI: 10.2147/cmar.s196919
• Publication Date: 2019-05-15T22:22:35Z
• Authors: Fei Ren; Weiwei Weng; Qiongyan Zhang; Cong Tan; Midie Xu; Meng Zhang; Lei Wang; Weiqi Sheng; Shujuan Ni; Dan Huang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Cancer Management and Research; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; prognosis; AFP-producing colorectal cancer; clinicopathological features; serum AFP; RC254-282; Original Research; 3. Good health

Background: High serum levels of alpha-fetoprotein (AFP) are observed in some gastrointestinal cancers. However, primary AFP-producing colorectal cancer (CRC) is extremely rare and causes confusion among clinicians. In this study, we analyzed the clinicopathological features clinical outcomes CRC provide a brief view carcinoma. Patients methods: Twenty patients with were enrolled at Fudan University Shanghai Cancer Center from 2012 to 2015. Clinical information, including AFP CEA levels, collected. Tumors divided into three histologic types: common adenocarcinoma (COM) type, mucinous type hepatoid (HPT). Immunohistochemical (IHC) staining GPC3, Hepa-1, SALL4 Arg-1 was performed. Additionally, mutations KRAS, NRAS BRAF genes examined. Finally, another 40 stage-matched traditional as controls for survival analysis. Results: more likely occur males (60%) arose mainly ascending (40%) sigmoid (35%) colon. addition, majority had poor differentiation (50%), advanced local invasion (80%) lymph node (LN) metastasis (60%). Synchronous distant commonly (35%). Interestingly, closely associated LN metastasis. Histopathologically, COM most pattern. IHC staining, HPT pattern distinct due high positivity rates Hepa-1 Arg-1. One patient mismatch repair deficiency, KRAS mutation. worse progression-free overall than CRC. Conclusion: has unique histopathological characteristics, showing an aggressive biological behavior prognosis Keywords: cancer, features, AFP,