<p>Estimation of radiotherapy modalities for patients with stage I-II nasal natural killer T-Cell lymphoma</p>

• DOI: 10.2147/cmar.s201514
• Publication Date: 2019-07-29T19:00:24Z
• Authors: Xianfeng Liu; Furong Wu; Qishuai Guo; Ying Wang; Yanan He; Huanli Luo; Qicheng Li; Mingsong Zhong; Chao Li; Han Yang; Juan Zhou; Fu Jin
• Keywords: Nasal natural killer T-Cell lymphoma; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; VMAT; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Cancer Management and Research; TomoHelical; Excess absolute risk; IMRT; RC254-282; Original Research

The objective of this study is to estimate radiotherapy (RT) modalities for patients with stage I-II nasal natural killer T-Cell lymphoma (NNKTCL), including plan quality, radiation delivery efficiency, cost RT and excess absolute risk (EAR).Twenty-four representative NNKTCL treated fix-field intensity-modulated (FF-IMRT) were re-planned volumetric modulated arc therapy (VMAT), TomoDirect (TD) TomoHelical (TH) on the TomoHDA system, respectively. Plan characteristics, EAR compared.Compared IMRT, TD TH showed significant improvement in terms D98%, D2%, cold spot volume homogeneity index (HI) planning target (PTV), while achieving worse Dmean conformity (CI). mean dose oropharynx, thyroid left salivary, maximum right salivary by (249.20%, p=0.000; 52.94%, 160.23%, p=0.022; 122.67%, p=0.027), VMAT (15.76%, 23.53%, 34.09%, 31.33%, p=0.000) (250.32%, 58.82%, 120.45%, p=0.020; 117.33%, p=0.032) increased significantly compared IMRT. reduced treatment time (p=0.000; 0.000; 0.000) monitor units (MUs) obviously TH. 150% IMRT VMAT. obtained lowest thyroid, gland four modalities.The results show that both can achieve higher conformal quality getting organs at (OARs) sparing some than NNKTCL. delivers most OARs, requires lower shortest time, optimal coverage. could provide direction selecting proper different cases.