Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes

• DOI: 10.2147/copd.s16383
• Publication Date: 2011-03-04T03:04:55Z
• Authors: N Hizawa; Hironori Masuko; Tohru Sakamoto; Yoshiko Kaneko; Hiroaki Iijima; Takashi Naito; Emiko Noguchi; Tomomitsu Hirota; Mayumi Tamari
• Keywords: Wheeze; Bronchial hyperresponsiveness

Abstract: Few studies have investigated the significance of decreased FEV 1 in non-COPD, nonasthmatic healthy subjects. We hypothesized that a lower these subjects is potential marker an increased susceptibility to obstructive lung disease such as asthma and COPD. This was cross-sectional analysis 1505 Japanese adults. divided population adults with no respiratory diseases whose /FVC ratio ≥70% (n = 1369) into 2 groups according their prebronchodilator (% predicted) measurements:<80% 217) ≥80% 1152). compared clinical data – including gender, age, smoking habits, total IgE levels, annual decline between groups. In addition, our group recently found TSLP variants are associated reduced function, we assessed whether single nucleotide polymorphisms (SNPs) were baseline function 1368). Although about half had never smoked, main risk factor for However, significantly higher independent status. Airflow obstruction levels serum ( P 0.029) functional SNPs (corrected 0.027–0.058 % predicted, corrected 0.015–0.033 /FVC). study highlights importance early recognition without evident pulmonary because it predicts rapid irrespective Our series identified locus subjects, which may support contention genetic determinants influence asthma. Keywords: airflow obstruction, asthma, chronic disease, test, thymic stromal lymphopoietin