<p>Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease</p>

• DOI: 10.2147/copd.s210598
• Publication Date: 2019-09-03T00:26:50Z
• Authors: Wenqi Diao; Wassim W Labaki; MeiLan Han; Larisa Yeomans; Yihan Sun; Zyad Smiley; Jae Hyun Kim; Cora McHugh; Pingchao Xiang; Ning Shen; Xiaoyan Sun; Chenxia Guo; Ming Lu; Theodore J Standi...; Bei He; Kathleen A Stringer
• Keywords: Adult; Male; 0301 basic medicine; China; Magnetic Resonance Spectroscopy; International Journal of Chronic Obstructive Pulmonary Disease; chronic obstructive pulmonary disease; Diseases of the respiratory system; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; Homeostasis; Humans; Metabolomics; Histidine; energy homeostasis; Original Research; Aged; Retrospective Studies; Aged, 80 and over; RC705-779; histidine; Middle Aged; metabolomics; 3. Good health; inflammation; Spirometry; Energy Metabolism; Tomography, X-Ray Computed; Biomarkers; Follow-Up Studies

Chronic obstructive pulmonary disease (COPD) is a systemic condition that too complex to be assessed by lung function alone. Metabolomics has the potential help understand mechanistic underpinnings contribute COPD pathogenesis. Since blood metabolomics may affected sex and body mass index (BMI), aim of this study was determine metabolomic variability in male smokers with without who have narrow BMI range. We compared quantitative proton nuclear magnetic resonance acquired serum Chinese Han population non-smokers COPD, COPD. also impact smoking status on metabolite concentrations associations between inflammatory markers such as interleukin-6 histamine, cell differential (%). data were log-transformed auto-scaled for parametric statistical analysis. Mean normalized concentration values continuous demographic variables Student's t-test Welch correction or ANOVA post-hoc Tukey's test, applicable; p-values corrected false discovery rate (FDR). A Pearson association matrix built evaluate relationship concentrations, clinical parameters inflammation. Twenty-eight metabolites identified quantified. Creatine, glycine, histidine, threonine reduced patients non-COPD (FDR ≤15%). Concentrations these inversely correlated levels. had overall dampening including energy-related metabolic pathways creatine metabolism. They higher histamine levels percent basophils associated alterations metabolome, disruption histidine-histamine pathways. These findings support use pathogenic mechanisms involved COPD.Trial registration www.clinicaltrials.gov, NCT03310177.