<p>Plasma Metabolomics and Lipidomics Reveal Perturbed Metabolites in Different Disease Stages of Chronic Obstructive Pulmonary Disease</p>

• DOI: 10.2147/copd.s229505
• Publication Date: 2020-03-09T01:26:55Z
• Authors: Juntuo Zhou; Qiuyu Li; Chengyang Liu; Ruifang Pang; Yuxin Yin
• Keywords: Metabolome

Background: Chronic obstructive pulmonary disease (COPD) is a common characterized by persistent respiratory symptoms and airflow restriction. It usually manifested as airway and/or alveolar abnormalities caused significant exposure to harmful particulates or gases. Objective: We aim explore plasma metabolomic changes in the acute exacerbation stage of COPD (AECOPD) stable (Stable COPD) identify potential biomarkers for diagnosis prognosis clinical practice. Methods: Untargeted metabolomics lipidomics analyses were performed investigate dysregulated molecules blood AECOPD patients (n=48) Stable (n=48), cohort healthy people included control group (n=48). Statistical analysis bioinformatics reveal metabolites perturbed metabolic pathways. SVM-based multivariate ROC was used candidate biomarker screening. Results: A total 142 688 lipids patients. Pathway enrichment showed that several pathways after onset. Several panels proposed vs with AUC greater than 0.9. Conclusion: Numerous detected relevant onset progression. These may be considered COPD. The involved provide clues further pathological mechanism studies Keywords: metabolomics, lipidomics, COPD,