<p>Malnutrition, Airflow Limitation and Severe Emphysema are Risks for Exacerbation of Chronic Obstructive Pulmonary Disease in Japanese Subjects: A Retrospective Single-Center Study</p>

• DOI: 10.2147/copd.s238457
• Publication Date: 2020-04-21T20:52:28Z
• Authors: Mutsuo Yamaya; Osamu Usami; Shoichi Nakayama; Naoki Tode; Aya Yamada; Shunsuke Ito; Fumiya Omata; Haruki Momma; Masakatsu Funakubo; Masakazu Ichinose
• Keywords: Hypoalbuminemia; Hypoproteinemia; Univariate analysis

Background: Different characteristics of patients with chronic obstructive pulmonary disease (COPD) between Western and Japanese populations have been reported. Risk factors for COPD exacerbation reported in countries but not studied Japan. Patients Methods: We retrospectively examined risk exacerbation. A total 156 were enrolled, the records 136 analyzed. Results: In group (n=60), body mass index, forced vital capacity (FVC), expiratory volume one second (FEV 1 ), FEV /FVC ratio /FVC), percent predicted values (%FEV serum protein (TP) albumin concentrations lower, age, mortality rate, frequency common cold pneumonia, severity rankings, modified Medical Research Council (mMRC) dyspnea score, proportions severe emphysema (> 50% low attenuation area) receiving long-term oxygen therapy higher than those nonexacerbation (n=76). However, proportion a greater number eosinophils (≥ 200/μL and/or ≥ 2%) exhaled nitric oxide concentration did differ two groups. univariate analysis, age; therapy; FVC, , %FEV ; high ranking mMRC score; emphysema; hypoproteinemia (< 6.5 g/dL); hypoalbuminemia 3.5 leukocytosis; lymphocytopenia; anemia. multivariate hypoalbuminemia, . Additionally, exacerbation-induced subgroup, frequency, score lymphocytopenia higher, %FVC, TP lymphocyte lower survival subgroup. Conclusion: Malnutrition, airflow limitation risks associated infection COPD. Keywords: malnutrition, disease, exacerbation, emphysema,